of April 6 , 2017 . This information is current as Fimbriae Is a Novel TLR 4 Ligand Cutting Edge : FimH

In silico Study of Toll-Like Receptor 4 Binding Site of FimH from Uropathogenic Escherichia coli

  Introduction : The innate immune system as the first line of defense against the pathogens recognizes pathogen-associated molecular patterns (PAMPs) by Toll-Like Receptors (TLRs). Interaction of bacterial PAMPs by TLRs results in activation of innate and acquired immunity. FimH adhesin, a minor component of type 1 fimbriae encoded by Uropathogenic Escherichia coli (UPEC) is a PAMP of TLR4 tha...

Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding

The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E. coli clinical isolates express the FimH adhesin, which consists of a mannose-specific lectin domain connected via a pilin domain to the tip of type 1 pili. Although the isolated FimH lectin domain has affinities in the nanomola...

of April 14 , 2017 . This information is current as Receptor 1 and IL - 10 Receptor 2 Receptor Complex Composed of IL - 20 Cutting Edge : IL - 26 Signals through a Novel Kotenko

Uncoiling Mechanics of Escherichia coli Type I Fimbriae Are Optimized for Catch Bonds

We determined whether the molecular structures through which force is applied to receptor-ligand pairs are tuned to optimize cell adhesion under flow. The adhesive tethers of our model system, Escherichia coli, are type I fimbriae, which are anchored to the outer membrane of most E. coli strains. They consist of a fimbrial rod (0.3-1.5 microm in length) built from a helically coiled structural ...

Frequency of selected virulence-associated genes in intestinal and extra-intestinal Escherichia coli isolates from chicken

Background: Although Escherichia coli (E. coli)is a part of intestinal normal microflora of warm-blooded animals, includingpoultry, outbreaks occur in poultry raised below standard sanitation and duringthe course of respiratory or immunosuppressive diseases. Avian pathogenic E.coli (APEC) harbors several genes associated with virulence andpathogenicity. APEC strains are responsible for some dis...